Chloroquine/sulphadoxine-pyrimethamine for gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparum.

ABSTRACT:

Objectives

In the Gambia, chloroquine (CQ) plus sulphadoxine-pyrimethamine (SP) is the first-line antimalarial treatment. Plasmodium falciparum parasites carrying mutations associated with resistance to each of these drugs were present in 2001 but did not cause a significant loss of therapeutic efficacy among children receiving the combination CQ/SP. We measured their effect on parasite transmission to Anopheles gambiae mosquitoes.

Design

We conducted a single-blind, randomised, controlled trial with follow-up over 28 d. Mosquito feeding experiments were carried out 7, 10, or 14 d after treatment.

Setting

The study took place in the town of Farafenni and surrounding villages in the Gambia.

Participants

Participants were 500 children aged 6 mo to 10 y with uncom

SUBMITTER: Hallett RL 

PROVIDER: S-EPMC1513405 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature