Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum.

ABSTRACT:

Objectives

In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence of parasites carrying alleles associated with resistance to CQ or SP.

Design

We conducted a single-blind, randomised, controlled trial to compare the efficacy of CQ/SP to that of SP or CQ alone.

Setting

The study took place in the town of Farafenni and surrounding villages in the Gambia.

Participants

Participants were children aged 12 mo to 10 y presenting as outpatients with uncomplicated P. falciparum malaria.

Interventions

500 children were randomised to receive CQ, SP, or CQ/SP as supervised treatment

SUBMITTER: Dunyo S 

PROVIDER: S-EPMC1513406 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature