ProFace: a server for the analysis of the physicochemical features of protein-protein interfaces.

ABSTRACT:

Background

Molecular recognition is all pervasive in biology. Protein molecules are involved in enzyme regulation, immune response, signal transduction, oligomer assembly, etc. Delineation of physical and chemical features of the interface formed by protein-protein association would allow us to better understand protein interaction networks on one hand, and to design molecules that can engage a given interface and thereby control protein function on the other hand.

Results

ProFace is a suite of programs that uses a file, containing atomic coordinates of a multi-chain molecule, as input and analyzes the interface between any two or more subunits. The interface residues are shown segregated into spatial patches (if such a clustering is possible based on an input threshold dist

SUBMITTER: Saha RP 

PROVIDER: S-EPMC1513576 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature