Regulation of host cell transcriptional physiology by the avian pneumovirus provides key insights into host-pathogen interactions.

ABSTRACT: Infection with a viral pathogen triggers several pathways in the host cell that are crucial to eliminating infection, as well as those that are used by the virus to enhance its replication and virulence. We have here used suppression subtractive hybridization and cDNA microarray analyses to characterize the host transcriptional response in an avian pneumovirus model of infection. The results of our investigations reveal a dynamic host response that includes the regulation of genes with roles in a vast array of cellular functions as well as those that have not been described previously. The results show a considerable upregulation in transcripts representing the interferon-activated family of genes, predicted to play a role in virus replication arrest. The analysis also identified transcrip

SUBMITTER: Munir S 

PROVIDER: S-EPMC152140 | biostudies-literature | 2003 Apr

REPOSITORIES: biostudies-literature