Meta-analysis discovery of tissue-specific DNA sequence motifs from mammalian gene expression data.

ABSTRACT:

Background

A key step in the regulation of gene expression is the sequence-specific binding of transcription factors (TFs) to their DNA recognition sites. However, elucidating TF binding site (TFBS) motifs in higher eukaryotes has been challenging, even when employing cross-species sequence conservation. We hypothesized that for human and mouse, many orthologous genes expressed in a similarly tissue-specific manner in both human and mouse gene expression data, are likely to be co-regulated by orthologous TFs that bind to DNA sequence motifs present within noncoding sequence conserved between these genomes.

Results

We performed automated motif searching and merging across four different motif finding algorithms, followed by filtering of the resulting motifs for those that con

SUBMITTER: Huber BR 

PROVIDER: S-EPMC1522027 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature