Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction.

ABSTRACT: The identification of antigens associated with tumor destruction is a major goal of cancer immunology. Vaccination with irradiated tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor generates potent, specific, and long-lasting antitumor immunity through improved tumor antigen presentation by dendritic cells and macrophages. A phase I clinical trial of this immunization strategy in patients with disseminated melanoma revealed the consistent induction in distant metastases of dense T and B cell infiltrates that effectuated substantial tumor necrosis and fibrosis. To delineate the target antigens of this vaccine-stimulated tumor destruction, we screened a melanoma cDNA expression library with postimmunization sera from a long-term responding patient (K030). Hig

SUBMITTER: Schmollinger JC 

PROVIDER: S-EPMC152304 | biostudies-literature | 2003 Mar

REPOSITORIES: biostudies-literature