Association study of the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia.

ABSTRACT:

Background

Brahma (BRM) is a key component of the multisubunit SWI/SNF complex, a complex which uses the energy of ATP hydrolysis to remodel chromatin. BRM contains an N-terminal polyglutamine domain, encoded by a polymorphic trinucleotide (CAA/CAG) repeat, the only known polymorphism in the coding region of the gene (SMARCA2). We have examined the association of this polymorphism with schizophrenia in a family-based and case/control study. SMARCA2 was chosen as a candidate gene because of its specific role in developmental pathways, its high expression level in the brain and some evidence of its association with schizophrenia spectrum disorder from genome-wide linkage analysis.

Results

Family-based analysis with 281 complete and incomplete triads showed that there is no sig

SUBMITTER: Sengupta S 

PROVIDER: S-EPMC1523194 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature