CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer.

ABSTRACT:

Background

The E-cadherin gene (CDH1) maps, at chromosome 16q22.1, a region often associated with loss of heterozygosity (LOH) in human breast cancer. LOH at this site is thought to lead to loss of function of this tumor suppressor gene and was correlated with decreased disease-free survival, poor prognosis, and metastasis. Differential CpG island methylation in the promoter region of the CDH1 gene might be an alternative way for the loss of expression and function of E-cadherin, leading to loss of tissue integrity, an essential step in tumor progression.

Methods

The aim of our study was to assess, by Methylation-Specific Polymerase Chain Reaction (MSP), the methylation pattern of the CDH1 gene and its possible correlation with the expression of E-cadherin and other standard

SUBMITTER: Caldeira JR 

PROVIDER: S-EPMC1523210 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature