Design of microarray probes for virus identification and detection of emerging viruses at the genus level.

ABSTRACT:

Background

Most virus detection methods are geared towards the detection of specific single viruses or just a few known targets, and lack the capability to uncover the novel viruses that cause emerging viral infections. To address this issue, we developed a computational method that identifies the conserved viral sequences at the genus level for all viral genomes available in GenBank, and established a virus probe library. The virus probes are used not only to identify known viruses but also for discerning the genera of emerging or uncharacterized ones.

Results

Using the microarray approach, the identity of the virus in a test sample is determined by the signals of both genus and species-specific probes. The genera of emerging and uncharacterized viruses are determined based

SUBMITTER: Chou CC 

PROVIDER: S-EPMC1523220 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature