A randomised trial comparing genotypic and virtual phenotypic interpretation of HIV drug resistance: the CREST study.

ABSTRACT:

Objectives

The aim of this study was to compare the efficacy of different HIV drug resistance test reports (genotype and virtual phenotype) in patients who were changing their antiretroviral therapy (ART).

Design

Randomised, open-label trial with 48-week followup.

Setting

The study was conducted in a network of primary healthcare sites in Australia and New Zealand.

Participants

Patients failing current ART with plasma HIV RNA > 2000 copies/mL who wished to change their current ART were eligible. Subjects were required to be > 18 years of age, previously treated with ART, have no intercurrent illnesses requiring active therapy, and to have provided written informed consent.

Interventions

Eligible subjects were randomly assigned to receive a genotype (grou

SUBMITTER: Hales G 

PROVIDER: S-EPMC1523224 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature