The influence of injection rate on the hypnotic effect of propofol during anesthesia: a randomized trial.

ABSTRACT:

Objective

Previous studies suggested that slow injection of propofol may increase the hypnotic effect during induction of anesthesia. The aim of the present study was therefore to investigate whether injection rate of propofol has an influence on its maximum effect.

Design

Randomized, single-blind trial.

Setting

This study has been carried out in the operating rooms of a university hospital. An anesthesiologist and a resident performed the study with the aid of changing nursing staff.

Participants

We investigated 99 unpremedicated patients aged 18 to 60 years with American Society of Anesthesiologists (ASA) physical status 1-3.

Interventions

Anesthesia was induced by intravenous injection of propofol (2 mg/kg). Propofol was manually injected in group 1 o

SUBMITTER: Blum J 

PROVIDER: S-EPMC1523225 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature