A phylogenomic gene cluster resource: the Phylogenetically Inferred Groups (PhIGs) database.

ABSTRACT:

Background

We present here the PhIGs database, a phylogenomic resource for sequenced genomes. Although many methods exist for clustering gene families, very few attempt to create truly orthologous clusters sharing descent from a single ancestral gene across a range of evolutionary depths. Although these non-phylogenetic gene family clusters have been used broadly for gene annotation, errors are known to be introduced by the artifactual association of slowly evolving paralogs and lack of annotation for those more rapidly evolving. A full phylogenetic framework is necessary for accurate inference of function and for many studies that address pattern and mechanism of the evolution of the genome. The automated generation of evolutionary gene clusters, creation of gene trees, determinat

SUBMITTER: Dehal PS 

PROVIDER: S-EPMC1523372 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature