Simple sequence proteins in prokaryotic proteomes.

ABSTRACT:

Background

The structural and functional features associated with Simple Sequence Proteins (SSPs) are non-globularity, disease states, signaling and post-translational modification. SSPs are also an important source of genetic and possibly phenotypic variation. Analysis of 249 prokaryotic proteomes offers a new opportunity to examine the genomic properties of SSPs.

Results

SSPs are a minority but they grow with proteome size. This relationship is exhibited across species varying in genomic GC, mutational bias, life style, and pathogenicity. Their proportion in each proteome is strongly influenced by genomic base compositional bias. In most species simple duplications is favoured, but in a few cases such as Mycobacteria, large families of duplications occur. Amino acid prefer

SUBMITTER: Subramanyam MB 

PROVIDER: S-EPMC1524752 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature