Adaptive evolution in two large families of ubiquitin-ligase adapters in nematodes and plants.

ABSTRACT: Host-pathogen arms races can result in adaptive evolution (positive selection) of host genes that mediate pathogen recognition and defense. To identify such genes in nematodes, I used maximum-likelihood analysis of codon evolution to survey all paralogous gene groups in Caenorhabditis elegans. This survey found robust evidence of positive selection in two classes of genes not previously implicated in pathogen defense. Both classes of genes encode ubiquitin-dependent proteasome adapters, which recruit diverse substrate proteins for poly-ubiquitination and proteolysis by Cullin-E3 ubiquitin-ligase complexes. The adapter proteins are members of the F-box superfamily and the MATH-BTB family, which consist of a conserved Cullin-binding domain and a variable substrate-binding domain. Further ana

SUBMITTER: Thomas JH 

PROVIDER: S-EPMC1524861 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature