The regulated expression of chimeric tyrosine hydroxylase-insulin transcripts during early development.

ABSTRACT: Biological complexity does not appear to be simply correlated with gene number but rather other mechanisms contribute to the morphological and functional diversity across phyla. Such mechanisms regulate different transcriptional, translational and post-translational processes and include the recently identified transcription induced chimerism (TIC). We have found two novel chimeric transcripts in the chick and quail that result from the fusion of tyrosine hydroxylase (TH) and insulin into a single mature transcript. The th and insulin genes are located in tandem and they are generally transcribed independently. However, it appears that two chimeric transcripts containing exons from both the genes can also be produced in a regulated manner. The TH-INS1 and TH-INS2 chimeras differ in their i

SUBMITTER: Hernandez-Sanchez C 

PROVIDER: S-EPMC1524912 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature