PRED(TAP): a system for prediction of peptide binding to the human transporter associated with antigen processing.

ABSTRACT:

Background

The transporter associated with antigen processing (TAP) is a critical component of the major histocompatibility complex (MHC) class I antigen processing and presentation pathway. TAP transports antigenic peptides into the endoplasmic reticulum where it loads them into the binding groove of MHC class I molecules. Because peptides must first be transported by TAP in order to be presented on MHC class I, TAP binding preferences should impact significantly on T-cell epitope selection.

Description

PRED(TAP) is a computational system that predicts peptide binding to human TAP. It uses artificial neural networks and hidden Markov models as predictive engines. Extensive testing was performed to valid the prediction models. The results showed that PRED(TAP) was both sensi

SUBMITTER: Zhang GL 

PROVIDER: S-EPMC1524936 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature