Differential expression of a new isoform of DLG2 in renal oncocytoma.

ABSTRACT:

Background

Renal oncocytoma, a benign tumour of the kidney, may pose a differential diagnostic problem due to overlapping phenotype with chromophobe renal cell carcinoma or other types of renal cell tumours. Therefore, identification of molecular markers would be of great value for molecular diagnostics of this tumour type.

Methods

In the current study we applied various techniques, including Affymetrix microarray hybridization and semiquantitative RT-PCR, to identify genes expressed differentially in renal oncocytomas. Subsequently, we used RACE and Northern blot hybridization to characterize the potential candidates for molecular diagnosis.

Results

We have identified new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothet

SUBMITTER: Zubakov D 

PROVIDER: S-EPMC1524971 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature