Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population.

ABSTRACT:

Background

The protein tyrosine phosphatase-1B, a negative regulator for insulin and leptin signalling, potentially modulates glucose and energy homeostasis. PTP1B is encoded by the PTPN1 gene located on chromosome 20q13 showing linkage with type 2 diabetes (T2D) in several populations. PTPN1 gene variants have been inconsistently associated with T2D, and the aim of our study was to investigate the effect of PTPN1 genetic variations on the risk of T2D, obesity and on the variability of metabolic phenotypes in the French population.

Methods

Fourteen single nucleotide polymorphisms (SNPs) spanning the PTPN1 locus were selected from previous association reports and from HapMap linkage disequilibrium data. SNPs were evaluated for association with T2D in two case-control groups w

SUBMITTER: Cheyssac C 

PROVIDER: S-EPMC1525165 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature