Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes.

ABSTRACT:

Background

Mouse and human skeletal muscle transcriptome profiles vary by muscle type, raising the question of which mouse muscle groups have the greatest molecular similarities to human skeletal muscle.

Methods

Orthologous (whole, sub-) transcriptome profiles were compared among four mouse-human transcriptome datasets: (M) six muscle groups obtained from three mouse strains (wildtype, mdx, mdx5cv); (H1) biopsied human quadriceps from controls and Duchenne muscular dystrophy patients; (H2) four different control human muscle types obtained at autopsy; and (H3) 12 different control human tissues (ten non-muscle).

Results

Of the six mouse muscles examined, mouse soleus bore the greatest molecular similarities to human skeletal muscles, independent of the latters' anatom

SUBMITTER: Kho AT 

PROVIDER: S-EPMC1525166 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature