Comparative analysis and integrative classification of NCI60 cell lines and primary tumors using gene expression profiling data.

ABSTRACT:

Background

NCI60 cell lines are derived from cancers of 9 tissue origins and have been invaluable in vitro models for cancer research and anti-cancer drug screen. Although extensive studies have been carried out to assess the molecular features of NCI60 cell lines related to cancer and their sensitivities to more than 100,000 chemical compounds, it remains unclear if and how well these cell lines represent or model their tumor tissues of origin. Identification and confirmation of correct origins of NCI60 cell lines are critical to their usage as model systems and to translate in vitro studies into clinical potentials. Here we report a direct comparison between NCI60 cell lines and primary tumors by analyzing global gene expression profiles.

Results

Comparative analysis sugge

SUBMITTER: Wang H 

PROVIDER: S-EPMC1525183 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature