Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms.

ABSTRACT:

Background

HSP90 proteins are essential molecular chaperones involved in signal transduction, cell cycle control, stress management, and folding, degradation, and transport of proteins. HSP90 proteins have been found in a variety of organisms suggesting that they are ancient and conserved. In this study we investigate the nuclear genomes of 32 species across all kingdoms of organisms, and all sequences available in GenBank, and address the diversity, evolution, gene structure, conservation and nomenclature of the HSP90 family of genes across all organisms.

Results

Twelve new genes and a new type HSP90C2 were identified. The chromosomal location, exon splicing, and prediction of whether they are functional copies were documented, as well as the amino acid length and molecular

SUBMITTER: Chen B 

PROVIDER: S-EPMC1525184 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature