Genomic divergences among cattle, dog and human estimated from large-scale alignments of genomic sequences.

ABSTRACT:

Background

Approximately 11 Mb of finished high quality genomic sequences were sampled from cattle, dog and human to estimate genomic divergences and their regional variation among these lineages.

Results

Optimal three-way multi-species global sequence alignments for 84 cattle clones or loci (each >50 kb of genomic sequence) were constructed using the human and dog genome assemblies as references. Genomic divergences and substitution rates were examined for each clone and for various sequence classes under different functional constraints. Analysis of these alignments revealed that the overall genomic divergences are relatively constant (0.32-0.37 change/site) for pairwise comparisons among cattle, dog and human; however substitution rates vary across genomic regions and amo

SUBMITTER: Liu GE 

PROVIDER: S-EPMC1525190 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature