A microarray analysis of gene expression in the free-living stages of the parasitic nematode Strongyloides ratti.

ABSTRACT:

Background

The nematode Strongyloides ratti has two adult phases in its lifecycle: one obligate, female and parasitic and one facultative, dioecious and free-living. The molecular control of the development of this free-living generation remains to be elucidated.

Results

We have constructed an S. ratti cDNA microarray and used it to interrogate changes in gene expression during the free-living phase of the S. ratti life-cycle. We have found very extensive differences in gene expression between first-stage larvae (L1) passed in faeces and infective L3s preparing to infect hosts. In L1 stages there was comparatively greater expression of genes involved in growth. We have also compared gene expression in L2 stages destined to develop directly into infective L3s with those desti

SUBMITTER: Thompson FJ 

PROVIDER: S-EPMC1525192 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature