The expression of p63 is associated with the differential stage in nasopharyngeal carcinoma and EBV infection.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) is common among Southern Chinese and the main histology is the undifferentiated carcinoma associated with Epstein-Barr virus (EBV) infection. p63 is a recently proved member of the p53 family based on the structural similarity to p53, but its function in NPC is still unknown. This study was aimed to investigate the association between p63 and NPC.

Results

p63 was expressed in 100% (202/202) of nasopharyngeal carcinoma (NPC) tissues but not in 29 nasopharynx inflammation and 17 non-cancerous nasopharyngeal epidermises on a tissue microarray by immunohistostaining. Further investigation suggested that the p63 expression was associated with the differential stage of NPC: p63 strong staining in Keratinizing squamous cell carcinoma, diffe

SUBMITTER: Guo C 

PROVIDER: S-EPMC1525203 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature