Infection with replication-deficient adenovirus induces changes in the dynamic instability of host cell microtubules.

ABSTRACT: Adenovirus translocation to the nucleus occurs through a well characterized minus end-directed transport along microtubules. Here, we show that the adenovirus infection process has a significant impact on the stability and dynamic behavior of host cell microtubules. Adenovirus-infected cells had elevated levels of acetylated and detyrosinated microtubules compared with uninfected cells. The accumulation of modified microtubules within adenovirus-infected cells required active RhoA. Adenovirus-induced changes in microtubule dynamics were characterized at the centrosome and at the cell periphery in living cells. Adenovirus infection resulted in a transient enhancement of centrosomal microtubule nucleation frequency. At the periphery of adenovirus-infected cells, the dynamic instability of mi

SUBMITTER: Warren JC 

PROVIDER: S-EPMC1525226 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature