Ontology highlight
ABSTRACT:
SUBMITTER: Deng M
PROVIDER: S-EPMC1525243 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Deng Maoxian M Chen Wei-Li WL Takatori Atsushi A Peng Zhimin Z Zhang Lin L Mongan Maureen M Parthasarathy Ranjani R Sartor Maureen M Miller Marian M Yang Jianhua J Su Bing B Kao Winston W-Y WW Xia Ying Y
Molecular biology of the cell 20060607 8
The mitogen-activated protein kinase kinase (MEK) kinase 1 (MEKK1) mediates activin B signals required for eyelid epithelium morphogenesis during mouse fetal development. The present study investigates the role of MEKK1 in epithelial wound healing, another activin-regulated biological process. In a skin wound model, injury markedly stimulates MEKK1 expression and activity, which are in turn required for the expression of genes involved in extracellular matrix (ECM) homeostasis. MEKK1 ablation or ...[more]