Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses.

ABSTRACT:

Background

High-throughput genotyping generates vast amounts of data for analysis; results can be difficult to summarize succinctly. A single project may involve genotyping many genes with multiple variants per gene and analyzing each variant in relation to numerous phenotypes, using several genetic models and population subgroups. Hundreds of statistical tests may be performed for a single SNP, thereby complicating interpretation of results and inhibiting identification of patterns of association.

Results

To facilitate visual display and summary of large numbers of association tests of genetic loci with multiple phenotypes, we developed a Phenotype-Genotype Association (PGA) grid display. A database-backed web server was used to create PGA grids from phenotypic and genotypi

SUBMITTER: Levy D 

PROVIDER: S-EPMC1526453 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature