Telomeric silencing of an open reading frame in Saccharomyces cerevisiae.

ABSTRACT: The endmost chromosome I ORF is silenced by a natural telomere position effect. YAR073W/IMD1 was found to be transcribed at much higher levels in sir3 mutants and when its adjacent telomere was removed from it. These results suggest that telomeres play a role in silencing actual genes.

SUBMITTER: Barton AB 

PROVIDER: S-EPMC1526490 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature