Challenges of detecting directional selection after a bottleneck: lessons from Sorghum bicolor.

ABSTRACT: Multilocus surveys of sequence variation can be used to identify targets of directional selection, which are expected to have reduced levels of variation. Following a population bottleneck, the signal of directional selection may be hard to detect because many loci may have low variation by chance and the frequency spectrum of variation may be perturbed in ways that resemble the effects of selection. Cultivated Sorghum bicolor contains a subset of the genetic diversity found in its wild ancestor(s) due to the combined effects of a domestication bottleneck and human selection on traits associated with agriculture. As a framework for distinguishing between the effects of demography and selection, we sequenced 204 loci in a diverse panel of 17 cultivated S. bicolor accessions. Genomewide patt

SUBMITTER: Hamblin MT 

PROVIDER: S-EPMC1526520 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature