A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases.

ABSTRACT: A systematic bioinformatic approach to identifying the evolutionarily conserved regions of proteins has verified the universality of a newly described conserved motif in RNA-dependent RNA polymerases (motif F). In combination with structural comparisons, this approach has defined two regions that may be involved in unwinding double-stranded RNA (dsRNA) for transcription. One of these is the N-terminal portion of motif F and the second is a large insertion in motif F present in the RNA-dependent RNA polymerases of some dsRNA viruses.

SUBMITTER: Bruenn JA 

PROVIDER: S-EPMC152793 | biostudies-literature | 2003 Apr

REPOSITORIES: biostudies-literature