Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers.

ABSTRACT: To identify metabolic features that support the aggressive behavior of human neuroendocrine (NE) cancers, we examined metastatic prostate NE tumors and derived prostate NE cancer (PNEC) cell lines from a transgenic mouse model using a combination of magic angle spinning NMR spectroscopy, in silico predictions of biotransformations that observed metabolites may undergo, biochemical tests of these predictions, and electrophysiological/calcium imaging studies. Malignant NE cells undergo excitation and increased proliferation when their GABA(A), glutamate, and/or glycine receptors are stimulated, use glutamate and GABA as substrates for NADH biosynthesis, and produce propylene glycol, a precursor of pyruvate derived from glycine that increases levels of circulating free fatty acids through ext

SUBMITTER: Ippolito JE 

PROVIDER: S-EPMC1533883 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature