Differences in the evolutionary history of disease genes affected by dominant or recessive mutations.

ABSTRACT:

Background

Global analyses of human disease genes by computational methods have yielded important advances in the understanding of human diseases. Generally these studies have treated the group of disease genes uniformly, thus ignoring the type of disease-causing mutations (dominant or recessive). In this report we present a comprehensive study of the evolutionary history of autosomal disease genes separated by mode of inheritance.

Results

We examine differences in protein and coding sequence conservation between dominant and recessive human disease genes. Our analysis shows that disease genes affected by dominant mutations are more conserved than those affected by recessive mutations. This could be a consequence of the fact that recessive mutations remain hidden from select

SUBMITTER: Furney SJ 

PROVIDER: S-EPMC1534034 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature