Genome-wide transcriptional analysis of temperature shift in L. interrogans serovar lai strain 56601.

ABSTRACT:

Background

Leptospira interrogans is an important mammalian pathogen. Transmission from an environmental source requires adaptation to a range of new environmental conditions in the organs and tissues of the infected host. Several studies have shown that a shift in culture temperature from 28 degrees C to 37 degrees C, similar to that encountered during infection of a host from an environmental source, is associated with differential synthesis of several proteins of the outer membrane, periplasm and cytoplasm. The whole genome of the Leptospira interrogans serogroup Icterohaemorrhagiae serovar lai type strain #56601 was sequenced in 2003 and microarrays were constructed to compare differential transcription of the whole genome at 37 degrees C and 28 degrees C.

Results

DNA mi

SUBMITTER: Qin JH 

PROVIDER: S-EPMC1534042 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature