Epigenetic properties of white-opaque switching in Candida albicans are based on a self-sustaining transcriptional feedback loop.

ABSTRACT: White-opaque switching in the human fungal pathogen Candida albicans is an alternation between two distinct types of cells, white and opaque. White and opaque cells differ in their appearance under the microscope, the genes they express, their mating behaviors, and the host tissues for which they are best suited. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. In this article, we identify a master regulator of white-opaque switching (Wor1), and we show that this protein is a transcriptional regulator that is needed to both establish and maintain the opaque state. We show that in opaque cells, Wor1 forms a positive feedback loop: It binds its own DNA regulatory region and activates its own transcription leading to the accum

SUBMITTER: Zordan RE 

PROVIDER: S-EPMC1535343 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature