Gene expression within a dynamic nuclear landscape.

ABSTRACT: Molecular imaging in living cells or organisms now allows us to observe macromolecular assemblies with a time resolution sufficient to address cause-and-effect relationships on specific molecules. These emerging technologies have gained much interest from the scientific community since they have been able to reveal novel concepts in cell biology, thereby changing our vision of the cell. One main paradigm is that cells stochastically vary, thus implying that population analysis may be misleading. In fact, cells should be analyzed within time-resolved single-cell experiments rather than being compared to other cells within a population. Technological imaging developments as well as the stochastic events present in gene expression have been reviewed. Here, we discuss how the structural organi

SUBMITTER: Shav-Tal Y 

PROVIDER: S-EPMC1538565 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature