Transposable element derived DNaseI-hypersensitive sites in the human genome.

ABSTRACT:

Background

Transposable elements (TEs) are abundant genomic sequences that have been found to contribute to genome evolution in unexpected ways. Here, we characterize the evolutionary and functional characteristics of TE-derived human genome regulatory sequences uncovered by the high throughput mapping of DNaseI-hypersensitive (HS) sites.

Results

Human genome TEs were found to contribute substantially to HS regulatory sequences characterized in CD4+ T cells: 23% of HS sites contain TE-derived sequences. While HS sites are far more evolutionarily conserved than non HS sites in the human genome, consistent with their functional importance, TE-derived HS sites are highly divergent. Nevertheless, TE-derived HS sites were shown to be functionally relevant in terms of driving gene

SUBMITTER: Marino-Ramirez L 

PROVIDER: S-EPMC1538576 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature