Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility.

ABSTRACT: A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C. albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C. glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.

SUBMITTER: Katiyar S 

PROVIDER: S-EPMC1538661 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature