MAVL/StickWRLD: analyzing structural constraints using interpositional dependencies in biomolecular sequence alignments.

ABSTRACT: The increasing availability of structurally aligned protein families has made it possible to use statistical methods to discover regions of interpositional dependencies of residue identity. Such dependencies amongst residues often have structural or functional implications, and their discovery can supply valuable constraints that assist in the refinement of measured, or predicted molecular structure assignments. Multiple Alignment Variation Linker (MAVL) and StickWRLD [W. Ray (2004) Nucleic Acids Res., 32, W59-W63] were developed to analyze and visualize nucleic acid and protein alignments, to discover and illuminate position/location relationships to the user. The original system analyzed users' data from a web-form submission and presented the user with a static VRML diagram describing t

SUBMITTER: Ozer HG 

PROVIDER: S-EPMC1538782 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature