Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools.

ABSTRACT: The vast amount of protein sequence data now available, together with accumulating experimental knowledge of protein function, enables modeling of protein sequence and function evolution. The PANTHER database was designed to model evolutionary sequence-function relationships on a large scale. There are a number of applications for these data, and we have implemented web services that address three of them. The first is a protein classification service. Proteins can be classified, using only their amino acid sequences, to evolutionary groups at both the family and subfamily levels. Specific subfamilies, and often families, are further classified when possible according to their functions, including molecular function and the biological processes and pathways they participate in. The second

SUBMITTER: Thomas PD 

PROVIDER: S-EPMC1538848 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature