QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences.

ABSTRACT: The quadruplex structures formed by guanine-rich nucleic acid sequences have received significant attention recently because of growing evidence for their role in important biological processes and as therapeutic targets. G-quadruplex DNA has been suggested to regulate DNA replication and may control cellular proliferation. Sequences capable of forming G-quadruplexes in the RNA have been shown to play significant roles in regulation of polyadenylation and splicing events in mammalian transcripts. Whether quadruplex structure directly plays a role in regulating RNA processing requires investigation. Computational approaches to study G-quadruplexes allow detailed analysis of mammalian genomes. There are no known easily accessible user-friendly tools that can compute G-quadruplexes in the nuc

SUBMITTER: Kikin O 

PROVIDER: S-EPMC1538864 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature