Protemot: prediction of protein binding sites with automatically extracted geometrical templates.

ABSTRACT:

Unlabelled

Geometrical analysis of protein tertiary substructures has been an effective approach employed to predict protein binding sites. This article presents the Protemot web server that carries out prediction of protein binding sites based on the structural templates automatically extracted from the crystal structures of protein-ligand complexes in the PDB (Protein Data Bank). The automatic extraction mechanism is essential for creating and maintaining a comprehensive template library that timely accommodates to the new release of PDB as the number of entries continues to grow rapidly. The design of Protemot is also distinctive by the mechanism employed to expedite the analysis process that matches the tertiary substructures on the contour of the query protein with the templat

SUBMITTER: Chang DT 

PROVIDER: S-EPMC1538868 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature