HARMONY: a server for the assessment of protein structures.

ABSTRACT: Protein structure validation is an important step in computational modeling and structure determination. Stereochemical assessment of protein structures examine internal parameters such as bond lengths and Ramachandran (varphi,psi) angles. Gross structure prediction methods such as inverse folding procedure and structure determination especially at low resolution can sometimes give rise to models that are incorrect due to assignment of misfolds or mistracing of electron density maps. Such errors are not reflected as strain in internal parameters. HARMONY is a procedure that examines the compatibility between the sequence and the structure of a protein by assigning scores to individual residues and their amino acid exchange patterns after considering their local environments. Local environm

SUBMITTER: Pugalenthi G 

PROVIDER: S-EPMC1538917 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature