Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio).

ABSTRACT:

Background

Integrins comprise a large family of alpha,beta heterodimeric, transmembrane cell adhesion receptors that mediate diverse essential biological functions. Higher vertebrates possess a single beta1 gene, and the beta1 subunit associates with a large number of alpha subunits to form the major class of extracellular matrix (ECM) receptors. Despite the fact that the zebrafish (Danio rerio) is a rapidly emerging model organism of choice for developmental biology and for models of human disease, little is currently known about beta1 integrin sequences and functions in this organism.

Results

Using RT-PCR, complete coding sequences of zebrafish beta1 paralogs were obtained from zebrafish embryos or adult tissues. The results show that zebrafish possess two beta1 paralogs (

SUBMITTER: Mould AP 

PROVIDER: S-EPMC1538996 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature