A methodology for global validation of microarray experiments.

ABSTRACT:

Background

DNA microarrays are popular tools for measuring gene expression of biological samples. This ever increasing popularity is ensuring that a large number of microarray studies are conducted, many of which with data publicly available for mining by other investigators. Under most circumstances, validation of differential expression of genes is performed on a gene to gene basis. Thus, it is not possible to generalize validation results to the remaining majority of non-validated genes or to evaluate the overall quality of these studies.

Results

We present an approach for the global validation of DNA microarray experiments that will allow researchers to evaluate the general quality of their experiment and to extrapolate validation results of a subset of genes to the rema

SUBMITTER: Miron M 

PROVIDER: S-EPMC1539027 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature