Transcriptomic analysis of extensive changes in metabolic regulation in Kluyveromyces lactis strains.

ABSTRACT: Genome-wide analysis of transcriptional regulation is generally carried out on well-characterized reference laboratory strains; hence, the characteristics of industrial isolates are therefore overlooked. In a previous study on the major cheese yeast Kluyveromyces lactis, we have shown that the reference strain and an industrial strain used in cheese making display a differential gene expression when grown on a single carbon source. Here, we have used more controlled conditions, i.e., growth in a fermentor with pH and oxygen maintained constant, to study how these two isolates grown in glucose reacted to an addition of lactose. The observed differences between sugar consumption and the production of various metabolites, ethanol, acetate, and glycerol, correlated with the response were monit

SUBMITTER: Suleau A 

PROVIDER: S-EPMC1539144 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature