DevA, a GntR-like transcriptional regulator required for development in Streptomyces coelicolor.

ABSTRACT: The gram-positive filamentous bacterium Streptomyces coelicolor has a complex developmental cycle with three distinct phases: growth of the substrate mycelium, development of reproductive structures called aerial hyphae, and differentiation of these aerial filaments into long chains of exospores. During a transposon mutagenesis screen, we identified a novel gene (devA) required for proper development. The devA mutant produced only rare aerial hyphae, and those that were produced developed aberrant spore chains that were much shorter than wild-type chains and had misplaced septa. devA encodes a member of the GntR superfamily, a class of transcriptional regulators that typically respond to metabolite effector molecules. devA forms an operon with the downstream gene devB, which encodes a puta

SUBMITTER: Hoskisson PA 

PROVIDER: S-EPMC1539961 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature