Transcriptional profile of Haemophilus influenzae: effects of iron and heme.

ABSTRACT: Haemophilus influenzae requires either heme or a porphyrin and iron source for growth. Microarray studies of H. influenzae strain Rd KW20 identified 162 iron/heme-regulated genes, representing approximately 10% of the genome, with > or =1.5-fold changes in transcription in response to iron/heme availability in vitro. Eighty genes were preferentially expressed under iron/heme restriction; 82 genes were preferentially expressed under iron/heme-replete conditions.

SUBMITTER: Whitby PW 

PROVIDER: S-EPMC1540045 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature