Genome-wide screening for cis-regulatory variation using a classical diallel crossing scheme.

ABSTRACT: Large-scale screening studies carried out to date for genetic variants that affect gene regulation are generally limited to descriptions of differences in allele-specific expression (ASE) detected in vivo. Allele-specific differences in gene expression provide evidence for a model whereby cis-acting genetic variation results in differential expression between alleles. Such gene surveys for regulatory variation are a first step in identifying the specific nucleotide changes that govern gene expression differences, but they leave the underlying mechanisms unexplored. Here, we propose a quantitative genetics approach to perform a genome-wide analysis of ASE differences (GASED). The GASED approach is based on a diallel design that is often used in plant breeding programs to estimate general co

SUBMITTER: Kiekens R 

PROVIDER: S-EPMC1540733 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature