A candidate metastasis-associated DNA marker for ductal mammary carcinoma.

ABSTRACT: BACKGROUND:Molecular genetic markers to identify the 13% lymph node-negative mammary carcinomas that are prone to develop metastases would clearly be of considerable value in indicating those cases in need of early aggressive therapy. METHODS:Representational difference analysis was used in an attempt to identify genetic alterations related to breast cancer metastasis by comparing genomic DNA from microdissected normal cells and from metastatic cells of ductal breast carcinoma patients. RESULTS:Representational difference analysis products yielded 10 unique metastasis-associated DNA sequences (MADS), i.e. products apparently lost in metastatic cell DNA. Of these sequences, MADS-IX was found to be lost in the transition from primary to metastasis in two out of five ductal breast carcinoma c

SUBMITTER: Achary PM 

PROVIDER: S-EPMC154149 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature