Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.

ABSTRACT:

Background

Candidate gene studies on the basis of biological hypotheses have been a practical approach to identify relevant genetic variation in complex traits. Based on previous reports and the roles in pain pathways, we have examined the effects of variations of loci in the genes of monoamine neurotransmitter systems including metabolizing enzymes, receptors and transporters on acute clinical pain responses in humans.

Results

Variations in the catecholamine metabolizing enzyme genes (MAOA and COMT) showed significant associations with the maximum post-operative pain rating while the serotonin transporter gene (SLC6A4) showed association with the onset time of post-operative pain. Analgesic onset time after medication was significantly associated with the norepinephrine tra

SUBMITTER: Kim H 

PROVIDER: S-EPMC1543620 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature